Vegetated coastal wetlands are subject to both longer term, climate-change driven stressors, such as warming and sea level rise, and more episodic stressors, such as changes in inundation, salinity, temperature, and nitrogen (N) loading, caused by heat waves and hurricanes. These stressors can alter greenhouse gas (GHG) emissions and can have a disproportionate effect on the annual GHG budget in vegetated coastal wetlands. We will discuss the interactive impact of multiple short-term stressors and multiple longer-term stressors on GHG emissions from coastal marshes using several mesocosm experiments as case studies.